Arthrosamid: A Targeted Solution for Pain Relief and Cushioning in Kneecap Osteoarthritis

Introduction

Patellofemoral osteoarthritis (kneecap OA) is a common cause of knee pain and limited movement, affecting many adults as they age. Arthrosamid is a modern treatment that uses a specially formulated gel injected directly into the knee joint . In this article, we’ll explore how Arthrosamid targets pain relief and adds cushioning to the kneecap. We’ll guide you through how it works, what the research says, what patients can expect from the treatment, and what you should know about its safety.

Understanding Patellofemoral Osteoarthritis

The patellofemoral joint is where your kneecap ( patella ) moves along the groove of your thigh bone (femur). Over time, the smooth cartilage in this joint can wear down, leading to pain, stiffness, and trouble bending or moving the knee. Factors like misalignment or increased pressure on the kneecap can speed up this process. People with kneecap OA often notice a sharp or aching pain at the front of the knee, sometimes with grinding or clicking noises, especially when climbing stairs or sitting for extended periods. Early symptoms can start as patellofemoral pain syndrome and gradually progress to full-blown osteoarthritis , highlighting the need for treatments that specifically address this part of the knee.

How Arthrosamid Hydrogel Cushions the Kneecap

Arthrosamid is made up of 97.5% water mixed with 2.5% polyacrylamide gel . It is injected directly into the knee joint in a quick procedure, with the injection guided by ultrasound for accuracy. Before the injection, a local anaesthetic numbs the area, and strict sterile techniques help prevent infection. Once in the joint, the gel thickens the joint fluid, helping it lubricate the joint more effectively and providing a cushioning layer to protect the cartilage from wear and tear. The gel also settles into the joint lining, creating a supportive structure that can last for months, all without the need for surgery. The entire procedure is minimally invasive and usually completed in a single clinic visit.

What the Research Says: Arthrosamid’s Effectiveness

Clinical studies show promising benefits for Arthrosamid in treating knee osteoarthritis . In a one-year trial, Arthrosamid worked at least as well as hyaluronic acid injections —a standard alternative—with some patients experiencing even greater improvement. Those under 70, of healthy weight, and with moderate knee damage tended to respond especially well. Other research comparing Arthrosamid to steroid injections found both provided relief, but Arthrosamid often offered longer-lasting benefits, with effects that can last up to two years. Patients consistently reported less knee pain and improved daily function. Still, results can vary from one person to the next, and ongoing studies are helping researchers understand which patients are most likely to benefit.

A recent study highlighted that older patients, those with lower grades of osteoarthritis , no diabetes, and those with both knees affected saw the most improvement following Arthrosamid treatment . Overall, the evidence supports Arthrosamid as a promising and lasting option for managing kneecap OA symptoms.

The Patient Journey: Expert Care at MSK Doctors with Professor Paul Lee

Successful outcomes with Arthrosamid depend on the expertise of your clinical team. At MSK Doctors, Professor Paul Lee —an experienced orthopaedic and rehabilitation specialist—leads a team dedicated to thorough patient care. Every patient receives a detailed assessment, including imaging and functional tests, to determine if Arthrosamid is the right choice. Treatment plans are built together, with open discussions about what to expect. Often, patients are also encouraged to take up physical therapy and lifestyle changes such as weight management to maximise the benefits of treatment.

Safety and Long-Term Considerations

Arthrosamid is generally very safe, with most patients experiencing only mild and temporary discomfort or swelling at the injection site. Serious side effects have not been reported in studies so far. Because the gel is non-biodegradable, it remains in the joint to provide continuous cushioning. Long-term follow-up studies show Arthrosamid remains effective and safe for up to three years, but results can vary, so regular check-ups are recommended. Ongoing research is helping to refine how the treatment is used and to better identify which patients will benefit most in the long run.

Conclusion

Arthrosamid represents a promising, minimally invasive option for those struggling with pain and stiffness from kneecap osteoarthritis . With expert guidance from the MSK Doctors team and Professor Paul Lee, patients can regain comfort and mobility—often without the need for surgery. If you’re considering Arthrosamid or want personalised advice about your knee pain, consult a qualified healthcare professional.

References

Gao, H. C. K., Akhtar, M., Creedon, C., Nar, Ö. O., & Lee, P. Y. (2025). THE IMPACT OF PATIENT FACTORS ON THE MINIMAL CLINICALLY IMPORTANT DIFFERENCE OF ARTHROSAMID POLYACRYLAMIDE HYDROGEL INJECTION FOR KNEE OSTEOARTHRITIS: A COHORT STUDY. Journal of Osteoarthritis and Cartilage. https://doi.org/10.1016/j.joca.2025.02.648

Hernandez Peña, V. W., & Vidal, J. (2020). Patellofemoral osteoarthritis: how do patients behave? Brazilian Journal of Implantology and Health Sciences, 2(12), 07-18. https://doi.org/10.36557/2674-8169.2020v2n12p07-18